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Research Supporting Hyperbaric Oxygen Therapy (HBOT)

At Hyperbaric Wellness Bismarck, we are dedicated to providing the most comprehensive and up-to-date insights into the benefits of Hyperbaric Oxygen Therapy (HBOT). Our curated collection of research highlights the diverse applications of HBOT, from enhancing brain function and supporting neurological recovery to reducing inflammation and optimizing overall wellness.

Many of the studies in our resource library offer decades of foundational knowledge on HBOT’s effectiveness, while new research continues to expand our understanding of its powerful impact. As advancements emerge, we remain committed to updating our database with the latest findings, ensuring you have access to the most relevant and scientifically backed information.

Whether you’re exploring HBOT for athletic recovery, neurological support, immune health, or overall vitality, our research hub provides valuable insights into how oxygen therapy is transforming health and healing.

Stay informed, explore the possibilities, and discover how HBOT is shaping the future of wellness. Visit us often for the latest updates and scientific discoveries in hyperbaric oxygen therapy.

HBOT Mechanism

Bhutani S, Vishwanath G. "Hyperbaric oxygen and wound healing." Indian Journal of Plastic Surgery. 2012;45(2):316–324. doi:10.4103/0970-0358.101309. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490679/

Thom SR. "Hyperbaric oxygen: its mechanisms and efficacy." Plastic and Reconstructive Surgery. 2011;127(Suppl 1):131S–141S. doi:10.1097/PRS.0b013e3181fbe2bf.

Link: https://journals.lww.com/plasreconsurg/fulltext/2011/01001/hyperbaric_oxygen__its_mechanisms_and_efficacy.23.aspx

Thom SR. "Oxidative stress is fundamental to hyperbaric oxygen therapy." Journal of Applied Physiology (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008. Link: https://journals.physiology.org/doi/full/10.1152/japplphysiol.91004.2008

Wingelaar TT, Brinkman P, van Ooij PJAM, et al. "Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis." Frontiers in Physiology. 2019;10:475. Published 2019 Apr 24. doi:10.3389/fphys.2019.00475.

Link: https://www.frontiersin.org/articles/10.3389/fphys.2019.00475/fullGill

AL, Bell CNA. "Hyperbaric oxygen: its uses, mechanisms of action and outcomes." QJM: An International Journal of Medicine. 2004;97(7):385–395. doi:10.1093/qjmed/hch074.

Link: https://academic.oup.com/qjmed/article/97/7/385/1567601

HBOT and General Health

Fife CE, Eckert KA, Carter MJ. "An update on the appropriate role for hyperbaric oxygen: indications and evidence." Plastic and Reconstructive Surgery. 2016;138(3 Suppl):107S–116S. doi:10.1097/PRS.0000000000002714.

Link: https://journals.lww.com/plasreconsurg/Fulltext/2016/09001/An_Update_on_the_Appropriate_Role_for_Hyperbaric.15.aspx

Thom SR. "Oxidative stress is fundamental to hyperbaric oxygen therapy." Journal of Applied Physiology (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008.

Link: https://journals.physiology.org/doi/full/10.1152/japplphysiol.91004.2008

Fujita N, Ono M, Tomioka T, et al. "Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration." PLoS One. 2014;9(12). Published 2014 Dec 22. doi:10.1371/journal.pone.0115685.

Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115685

Vadas D, Kalichman L, Hadanny A, et al. "Hyperbaric oxygen environment can enhance brain activity and multitasking performance." Frontiers in Integrative Neuroscience. 2017;11:25. Published 2017 Sep 27. doi:10.3389/fnint.2017.00025.

Link: https://www.frontiersin.org/articles/10.3389/fnint.2017.00025/full

Hink J, Jansen E. "Are superoxide and/or hydrogen peroxide responsible for some of the beneficial effects of hyperbaric oxygen therapy?" Medical Hypotheses. 2001;57(6):764–769.

Link: https://pubmed.ncbi.nlm.nih.gov/11747881/

HBOT and Dementia/Alzheimer’s

Harch PG, Fogarty EF. "Hyperbaric oxygen therapy for Alzheimer’s dementia with positron emission tomography imaging: a case report." Medical Gas Research. 2019;8(4):181–184. Published 2019 Jan 9. doi:10.4103/2045-9912.248271.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347177/

Shapira R, Efrati S, Ashery U. "Hyperbaric oxygen therapy as a new approach for Alzheimer’s disease." Neural Regeneration Research. 2018;13(5):817–818. doi:10.4103/1673-5374.232475.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953028/

Qiang L, Lan X, Su-qin X, et al. "Meta-Analysis on the Efficacy and Safety of Hyperbaric Oxygen as Adjunctive Therapy for Vascular Dementia." Frontiers in Aging Neuroscience. 2019;11:86. doi:10.3389/fnagi.2019.00086.

Link: https://www.frontiersin.org/articles/10.3389/fnagi.2019.00086/full

HBOT and Fibromyalgia

Efrati S, Golan H, Bechor Y, et al. "Hyperbaric oxygen therapy can diminish fibromyalgia syndrome–prospective clinical trial." PLoS One. 2015;10(5). Published 2015 May 26. doi:10.1371/journal.pone.0127012.

Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127012

Hadanny A, Bechor Y, Catalogna M, et al. "Hyperbaric oxygen therapy can induce neuroplasticity and significant clinical improvement in patients suffering from fibromyalgia with a history of childhood sexual abuse–randomized controlled trial." Frontiers in Psychology. 2018;9:2495. doi:10.3389/fpsyg.2018.02495.

Link: https://www.frontiersin.org/articles/10.3389/fpsyg.2018.02495/full

Efrati S, Hadanny A, Daphna-Tekoah S, et al. "Recovery of repressed memories in fibromyalgia patients managed with hyperbaric oxygen–case series presentation and suggested bio-psycho-social mechanism." Frontiers in Psychology. 2018;9:848. doi:10.3389/fpsyg.2018.00848.

Link: https://www.frontiersin.org/articles/10.3389/fpsyg.2018.00848/full

Yildiz S, Kiralp MZ, Akin A, et al. "A new modality for fibromyalgia syndrome: hyperbaric oxygen therapy." Journal of International Medical Research. 2004;32(3):263-267.

Link: https://journals.sagepub.com/doi/10.1177/147323000403200313

HBOT Sports Performance and Recovery

Seymour et al. "Hyperbaric Oxygen Therapy Enhances Athletic Recovery Through Physiological Adaptations." Frontiers in Physiology. 2021;12:791872. doi:10.3389/fphys.2021.791872.

Link: https://www.frontiersin.org/articles/10.3389/fphys.2021.791872/full

Shaw et al. "The Impact of Hyperbaric Oxygen Therapy on Athletic Performance and Recovery: A Comprehensive Review." Sports Medicine - Open. 2021;7(1):403. doi:10.1186/s40798-021-00403-w.

Link: https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-021-00403-w

HBOT and Autism

Rossignol DA, Bradstreet JJ, Van Dyke K, et al. "Hyperbaric oxygen in autism spectrum disorders." Medical Gas Research. 2012;2(1):16. doi:10.1186/2045-9912-2-16.Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447607/

Rossignol DA, Rossignol LW, Smith S, et al. "Hyperbaric for children with autism: a multicenter, randomized, double-blind, controlled trial." BMC Pediatrics. 2009;9:21. doi:10.1186/1471-2431-9-21.

Link: https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-9-21

Xiong T, Chen H, Luo R, et al. "Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD)." Cochrane Database of Systematic Reviews. 2016;10. doi:10.1002/14651858.CD010922.pub2.

Link: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010922.pub2/full

Rossignol DA, Rossignol LW. "Hyperbaric oxygen therapy may improve symptoms in autistic children." Medical Hypotheses. 2006;67(2):216-228. doi:10.1016/j.mehy.2006.02.009.

Link: https://www.sciencedirect.com/science/article/abs/pii/S0306987706001181

Rossignol DA, Frye RE. "Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism." Frontiers in Physiology. 2014;5:150. doi:10.3389/fphys.2014.00150.

Link: https://www.frontiersin.org/articles/10.3389/fphys.2014.00150/full

HBOT and Infection

Çimşit M, Uzun G, Yıldız S. "Hyperbaric oxygen therapy as an anti-infective agent." Expert Review of Anti-infective Therapy. 2009;7(8):1015-1026. doi:10.1586/eri.09.76.

Link: https://www.tandfonline.com/doi/full/10.1586/eri.09.76

Ezra N, Dang K, Heuser G. "Improvement of attention span and reaction time with hyperbaric oxygen in patients with toxic injury due to mold exposure." European Journal of Clinical Microbiology & Infectious Diseases. 2011;30(1):1–6. doi:10.1007/s10096-010-0937-8.

Link: https://link.springer.com/article/10.1007/s10096-010-0937-8

Mader JT, Brown GL, Guckian JC, et al. "A mechanism for the amelioration by hyperbaric oxygen of experimental staphylococcal osteomyelitis in rabbits." Journal of Infectious Diseases. 1980;142(6):915-922.Link: https://academic.oup.com/jid/article-abstract/142/6/915/2192487

Delasotta LA, Hanflik A, Bicking G, et al. "Hyperbaric oxygen for osteomyelitis in a compromised host." Open Orthopaedics Journal. 2013;7:114–117. doi:10.2174/1874325001307010114.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688397/

Ciofu O, Tolker-Nielsen T. "Tolerance and resistance of Pseudomonas aeruginosa biofilms to antimicrobial agents–how P. aeruginosa can escape antibiotics." Frontiers in Microbiology. 2019;10:913. doi:10.3389/fmicb.2019.00913.

Link: https://www.frontiersin.org/articles/10.3389/fmicb.2019.00913/full

Kolpen M, Lerche CJ, Kragh KN, et al. "Hyperbaric oxygen sensitizes anoxic pseudomonas aeruginosa biofilm to ciprofloxacin." Antimicrobial Agents and Chemotherapy. 2017;61(11). doi:10.1128/AAC.01024-17.

Link: https://journals.asm.org/doi/full/10.1128/AAC.01024-17

Gade PAV, Olsen TB, Jensen PØ, et al. "Modeling of ciprofloxacin killing enhanced by hyperbaric oxygen in Pseudomonas aeruginosa PAO1 biofilms." PLoS One. 2018;13(6). doi:10.1371/journal.pone.0198909.

Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198909

Memar MY, Yekani M, Alizadeh N, et al. "Hyperbaric oxygen therapy: antimicrobial mechanisms and clinical application for infections." Biomedicine & Pharmacotherapy. 2019;109:440-447. doi:10.1016/j.biopha.2018.10.142.

Link: https://www.sciencedirect.com/science/article/abs/pii/S0753332218310296

Kaye D. "Effect of hyperbaric oxygen on Clostridia in vitro and in vivo." Proceedings of the Society for Experimental Biology and Medicine. 1967;124:360.Link: https://journals.sagepub.com/doi/10.3181/00379727-124-31795

HBOT and Cancer (Including Keto)

İyikesici M, Slocum A, Slocum A, et al. "Efficacy of metabolically supported chemotherapy combined with ketogenic diet, hyperthermia, and hyperbaric oxygen therapy for stage IV triple-negative breast cancer." Cureus. 2017;9(7). doi:10.7759/cureus.1445.

Link: https://www.cureus.com/articles/7542

Poff AM, Ari C, Seyfried TN, et al. "The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer." PLoS One. 2013;8(6). doi:10.1371/journal.pone.0065522.Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065522

Seyfried TN, Mukherjee P. "The metabolic link between cancer and nutrition." Nutrition and Metabolism. 2005;2:30. doi:10.1186/1743-7075-2-30.Link: https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-2-30

Vander Heiden MG, Cantley LC, Thompson CB. "Understanding the Warburg effect: the metabolic requirements of cell proliferation." Science. 2009;324(5930):1029–1033. doi:10.1126/science.1160809.Link: https://www.science.org/doi/full/10.1126/science.1160809

Cancer (HBOT Only)

Moen I, Stuhr LE. "Hyperbaric oxygen therapy and cancer: a review." Target Oncology. 2012;7(4):233–242. doi:10.1007/s11523-012-0233-x.Link: https://link.springer.com/article/10.1007/s11523-012-0233-x

Thom SR, Bhopale VM, Yang M. "Microparticle-induced vascular injury in mice following decompression is inhibited by hyperbaric oxygen: effects on microparticles and interleukin-1." Journal of Applied Physiology. 2019;126(4):1093–1100.Link: https://journals.physiology.org/doi/full/10.1152/japplphysiol.00909.2018

Niezgoda JA, Serena TE, Carter MJ. "Outcomes of radiation injuries using hyperbaric oxygen therapy: an observational cohort study." Advances in Skin & Wound Care. 2016;29(1):12-19.Link: https://journals.lww.com/aswcjournal/Abstract/2016/01000/Outcomes_of_Radiation_Injuries_Using_Hyperbaric.5.aspx

Stepień K, Ostrowski RP, Matyja E. "Hyperbaric oxygen as an adjunctive therapy in the management of malignancies, including brain tumors." Medical Oncology. 2016;33(9):101. doi:10.1007/s12032-016-0814-0.Link: https://link.springer.com/article/10.1007/s12032-016-0814-0

Oscarsson N, Ny L, Mölne J, et al. "Hyperbaric oxygen reverses radiation-induced pro-fibrotic and oxidative stress responses in a rat model." Free Radical Biology and Medicine. 2017;103:248–255. doi:10.1016/j.freeradbiomed.2016.12.030.Link: https://www.sciencedirect.com/science/article/abs/pii/S0891584916311065

Zembrzuska K, Ostrowski RP, Matyja E. "Hyperbaric oxygen increases glioma cell sensitivity to antitumor drugs with a novel isothiourea derivative in vitro." Oncology Reports. 2019;41(5):2703–2716. doi:10.3892/or.2019.7064.Link: https://www.spandidos-publications.com/10.3892/or.2019.7064

Lu QZ, Li X, Ouyang J, et al. "Further application of hyperbaric oxygen in prostate cancer." Medical Gas Research. 2019;8(4):167–171. Published 2019 Jan 9. doi:10.4103/2045-9912.248268.Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347175/

Choudhury R. "Hypoxia and hyperbaric oxygen therapy: a review." International Journal of General Medicine. 2018;11:431–442. Published 2018 Nov 20. doi:10.2147/IJGM.S172460.Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248342/

HBOT and Wound Healing

Health Quality Ontario. "Hyperbaric oxygen therapy for the management of diabetic foot ulcers: a health technology assessment." Ontario Health Technology Assessment Series. 2017;17(5):1–142.Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461900/

Hou S, Wu G, Liang J, et al. "Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-α and IL-6 levels." Oncology Letters. 2019;17(3):3277–3282. doi:10.3892/ol.2019.10000.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394675/

Perren S, Gatt A, Papanas N, et al. "Hyperbaric oxygen therapy in ischemic foot ulcers in type 2 diabetes: a clinical trial." Open Cardiovascular Medicine Journal. 2018;12:80–85. Published 2018 Aug 31. doi:10.2174/1874192401812010080.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135494/

Eskes AM, Ubbink DT, Lubbers MJ, et al. "Hyperbaric oxygen therapy: solution for difficult-to-heal acute wounds? Systematic review." World Journal of Surgery. 2011;35(3):535–542. doi:10.1007/s00268-010-0923-4.

Link: https://link.springer.com/article/10.1007/s00268-010-0923-4

HBOT and TBI/Concussion

Boussi-Gross R, Golan H, Fishlev G, et al. "Hyperbaric oxygen therapy can improve post-concussion syndrome years after mild traumatic brain injury – randomized prospective trial." PLoS One. 2013;8(11):e79995. Published 2013 Nov 15. doi:10.1371/journal.pone.0079995.

Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079995

Tal S, Hadanny A, Sasson E, et al. "Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients." Frontiers in Human Neuroscience. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508.

Link: https://www.frontiersin.org/articles/10.3389/fnhum.2017.00508/full

Meng XE, Zhang Y, Li N, et al. "Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of TLR4/NF-κB signaling pathway." Medical Science Monitor. 2016;22:284–288. Published 2016 Jan 26. doi:10.12659/msm.894148.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730336/

Vlodavsky E, Palzur M, Feinsod M, et al. "Evaluation of the apoptosis-related proteins of the BCL-2 family in the traumatic penumbra area of the rat model of cerebral contusion, managed by hyperbaric oxygen therapy: a quantitative immunohistochemical study." Acta Neuropathologica. 2005;110(2):120-126.

Link: https://link.springer.com/article/10.1007/s00401-005-1054-8

Hadanny A, Abbott S, Suzin G, et al. "Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis." BMJ Open. 2018;8(9):e023387. Published 2018 Sep 28. doi:10.1136/bmjopen-2018-023387.

Link: https://bmjopen.bmj.com/content/8/9/e023387

Dong Y, Hu XH, Wu T, et al. "Effect of hyperbaric oxygenation therapy on post-concussion syndrome." Experimental and Therapeutic Medicine. 2018;16(3):2193–2202. doi:10.3892/etm.2018.6463.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112572/

Tsutsumi I, Tsujimoto Y, Takahashi S, et al. "Hyperbaric oxygen therapy for persistent post-concussion syndrome following mild traumatic brain injury." Cochrane Database of Systematic Reviews. 2017;2017(7):CD012727. doi:10.1002/14651858.CD012727.

Link: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012727/full

Eve DJ, Steele MR, Sanberg PR, et al. "Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury." Neuropsychiatric Disease and Treatment. 2016;12:2689–2705. doi:10.2147/NDT.S110126.

Link: https://www.dovepress.com/hyperbaric-oxygen-therapy-as-a-potential-treatment-for-post-traumatic--peer-reviewed-article-NDT

HBOT and Stroke Recovery

Rosario ER, Kaplan SE, Khonsari S, et al. "The effect of hyperbaric oxygen therapy on functional impairments caused by ischemic stroke." Neurology Research International. 2018;2018:3172679. doi:10.1155/2018/3172679.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192086/

Ostrowski RP, Stepien K, Pucko E, et al. "The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications." Archives of Medical Science. 2017;13(5):1217–1223. doi:10.5114/aoms.2017.65081.

Link: https://www.termedia.pl/The-efficacy-of-hyperbaric-oxygen-in-hemorrhagic-stroke-experimental-and-clinical-implications,19,28823,0,1.html

Efrati S, Fishlev G, Bechor Y, et al. "Hyperbaric oxygen induces late neuroplasticity in post-stroke patients–randomized, prospective trial." PLoS One. 2013;8(1):e53716. doi:10.1371/journal.pone.0053716.

Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053716

Liska GM, Lippert T, Russo E, et al. "A dual role for hyperbaric oxygen in stroke neuroprotection: preconditioning of the brain and stem cells." Conditioning Medicine. 2018;1(4):151–166.

Link: https://www.condmed.org/articles/A-Dual-Role-for-Hyperbaric-Oxygen-in-Stroke-Neuroprotection-Preconditioning-of-the-Brain-and-Stem-Cells/108

Hadanny A, Efrati S. "Oxygen–a limiting factor for brain recovery." Critical Care. 2015;19(1):307. doi:10.1186/s13054-015-1034-2.

Link: https://ccforum.biomedcentral.com/articles/10.1186/s13054-015-1034-2

Hadanny A, Golan H, Fishlev G, et al. "Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage." Restorative Neurology and Neuroscience. 2015;33(4):471–486. doi:10.3233/RNN-150517.

Link: https://content.iospress.com/articles/restorative-neurology-and-neuroscience/rnn150517

HBOT for PTSD

Link: https://www.dovepress.com/hyperbaric-oxygen-therapy-as-a-potential-treatment-for-post-traumatic--peer-reviewed-article-NDT

Harch PG, Andrews SR, Fogarty EF, et al. "Case control study: hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder." Medical Gas Research. 2017;7(3):156–174. doi:10.4103/2045-9912.215745.

Link: https://www.medgasres.com/article.asp?issn=2045-9912;year=2017;volume=7;issue=3;spage=156;epage=174;aulast=Harch

He H, Li X, He Y. "Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway." Neuropsychiatric Disease and Treatment. 2019;15:369–374. doi:10.2147/NDT.S183632.

Link: https://www.dovepress.com/hyperbaric-oxygen-therapy-attenuates-neuronal-apoptosis-induced-by-tra-peer-reviewed-article-NDT

HBOT and Other Neurological Issues

Nazario J, Kuffler DP. "Hyperbaric oxygen therapy and promoting neurological recovery following nerve trauma." Undersea and Hyperbaric Medicine. 2011;38(5):345–366.

Link: https://www.uhms.org/publications/journals/undersea-and-hyperbaric-medicine.html

Hu Q, Manaenko A, Xu T, et al. "Hyperbaric oxygen therapy for traumatic brain injury: bench-to-bedside." Medical Gas Research. 2016;6(2):102–110. Published 2016 Jul 11. doi:10.4103/2045-9912.184720.

Link: https://www.medgasres.com/article.asp?issn=2045-9912;year=2016;volume=6;issue=2;spage=102;epage=110;aulast=Hu

Taghizadeh Asl M, Nemati R, Chabi N, et al. "Brain perfusion imaging with voxel-based analysis in secondary progressive multiple sclerosis patients with a moderate to severe stage of disease: a boon for the workforce." BMC Neurology. 2016;16:79. doi:10.1186/s12883-016-0605-4.

Link: https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-016-0605-4

Kiralp MZ, Yildiz Ş, Vural D, et al. "Effectiveness of hyperbaric oxygen therapy in the treatment of complex regional pain syndrome." Journal of International Medical Research. 2004;32(3):258–262.

Link: https://journals.sagepub.com/doi/10.1177/147323000403200309

Oroglu B, Turker T, Aktas S, et al. "Effect of hyperbaric oxygen therapy on tensile repair of the peripheral nerves." Undersea and Hyperbaric Medicine. 2011;38(5):367–373.

Link: https://www.uhms.org/publications/journals/undersea-and-hyperbaric-medicine.html

Link: https://www.frontiersin.org/articles/10.3389/fnint.2017.00025/full

Hadanny A, Maliar A, Fishlev G, et al. "Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen." Clinical Ophthalmology. 2016;11:115–125. doi:10.2147/OPTH.S121307.

Link: https://www.dovepress.com/reversibility-of-retinal-ischemia-due-to-central-retinal-artery-occlus-peer-reviewed-article-OPTH

HBOT and Pain-Inflammation

Meng XE, Zhang Y, Li N, et al. "Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of TLR4/NF-κB signaling pathway." Medical Science Monitor. 2016;22:284–288. doi:10.12659/msm.894148.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730336/
Dulai PS, Gleeson MW, Taylor D, et al. "Systematic review: the safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease." Alimentary Pharmacology & Therapeutics. 2014;39(12):1266–1275. doi:10.1111/apt.12753.
Link: https://onlinelibrary.wiley.com/doi/10.1111/apt.12753
Hui J, Zhang ZJ, Zhang X, et al. "Repetitive hyperbaric oxygen treatment attenuates complete Freund’s adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord." Journal of Pain. 2013;14(7):747–758.
Link: https://pubmed.ncbi.nlm.nih.gov/23528604/
Li F, Fang L, Huang S, et al. "Hyperbaric oxygenation therapy alleviates chronic constrictive injury-induced neuropathic pain and reduces tumor necrosis factor-alpha production." Anesthesia & Analgesia. 2011;113(3):626–633.
Link: https://journals.lww.com/anesthesia-analgesia/Abstract/2011/09000/Hyperbaric_Oxygenation_Therapy_Alleviates_Chronic.25.aspx
Choudhury R. "Hypoxia and hyperbaric oxygen therapy: a review." International Journal of General Medicine. 2018;11:431–442. doi:10.2147/IJGM.S172460.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248342/

HBOT and Mitochondria

Palzur E, Zaaroor M, Vlodavsky E, et al. "Neuroprotective effect of hyperbaric oxygen therapy in brain injury is mediated by preservation of mitochondrial membrane properties." Brain Research. 2008;1221:126–133. doi:10.1016/j.brainres.2008.05.051.
Link: https://www.sciencedirect.com/science/article/abs/pii/S000689930800910X
Dave KR, Prado R, Busto R, et al. "Hyperbaric oxygen therapy protects against mitochondrial dysfunction and delays onset of motor neuron disease in wobbler mice." Neuroscience. 2003;120(1):113–120. doi:10.1016/S0306-4522(03)00244-6.
Link: https://www.sciencedirect.com/science/article/abs/pii/S0306452203002446
Meyer JN, Hartman JH, Mello DF. "Mitochondrial toxicity." Toxicological Sciences. 2018;162(1):15–23. doi:10.1093/toxsci/kfx236.
Link: https://academic.oup.com/toxsci/article/162/1/15/4818606
Meyer JN, Leung MC, Rooney JP, et al. "Mitochondria as a target of environmental toxicants." Toxicological Sciences. 2013;134(1):1–17. doi:10.1093/toxsci/kft102.
Link: https://academic.oup.com/toxsci/article/134/1/1/1663430

HBOT and Microbiome

Schmidt TM, Kao JY. "A little O2 may go a long way in structuring the GI microbiome." Gastroenterology. 2014;147(5):956–959. doi:10.1053/j.gastro.2014.09.025.
Link: https://www.gastrojournal.org/article/S0016-5085(14)01135-0/fulltext
Nyabanga CT, Kulkarni G, Shen B. "Hyperbaric oxygen therapy for chronic antibiotic-refractory ischemic pouchitis." Gastroenterology Report. 2017;5(4):320–321. doi:10.1093/gastro/gov038.
Link: https://academic.oup.com/gastro/article/5/4/320/3073986
Albenberg L, Esipova TV, Judge CP, et al. "Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota." Gastroenterology. 2014;147(5):1055–1063.e8. doi:10.1053/j.gastro.2014.07.020.
Link: https://www.gastrojournal.org/article/S0016-5085(14)00890-3/fulltext
Crabbé A, Jensen PO, Bjarnsholt T, et al. "Antimicrobial tolerance and metabolic adaptations in microbial biofilms." Trends in Microbiology. 2019;27(10):850–863. doi:10.1016/j.tim.2019.05.003.
Link: https://www.cell.com/trends/microbiology/fulltext/S0966-842X(19)30120-3

Hyperbaric Chamber FAQs

What is HBOT (Hyperbaric Oxygen Therapy)?

Hyperbaric Oxygen Therapy (HBOT) is a specialized wellness treatment that involves breathing concentrated oxygen inside a pressurized chamber. This increased pressure allows oxygen to dissolve more efficiently into the bloodstream, promoting faster recovery, enhanced cellular function, and overall well-being. Whether used for athletic recovery, inflammation reduction, or general health optimization, HBOT is a powerful tool for supporting the body's natural healing processes.

How do hyperbaric oxygen chambers work?

Inside a hyperbaric oxygen chamber, the increased air pressure allows your body to absorb a greater concentration of oxygen, delivering it more effectively to your tissues and cells. This process supports faster healing, reduces inflammation, and naturally boosts energy levels, helping your body recover and function optimally.

What are the benefits of using a hyperbaric chamber?

A hyperbaric oxygen chamber can help accelerate recovery, boost energy levels, improve sleep quality, and reduce inflammation. This therapy is beneficial for individuals looking to enhance their overall wellness and performance, as well as for clinics seeking to offer cutting-edge health and recovery solutions.

How long does a typical HBOT session last?

Most hyperbaric oxygen therapy (HBOT) sessions typically range from 60 to 90 minutes. The experience is calm and relaxing, giving you time to read, listen to music, or simply unwind while your body absorbs the benefits of increased oxygen levels.

How many sessions do I need with a hyperbaric chamber?

The number of hyperbaric oxygen therapy (HBOT) sessions varies based on individual health goals. Some people notice benefits after just a few sessions, while others choose to integrate HBOT into their regular wellness routine for long-term support and recovery.

Is a hyperbaric oxygen chamber safe to use?

Yes, hyperbaric oxygen chambers are designed to be safe, comfortable, and effective. When used properly, they provide a reliable way to support overall health, recovery, and wellness in a controlled environment.

Can anyone use a hyperbaric chamber?

Hyperbaric oxygen therapy (HBOT) offers benefits for a wide range of individuals, but the best approach depends on your personal health goals and wellness needs. Our team can help assess whether HBOT is a good fit for you and guide you on how to incorporate it into your wellness routine.

What should I expect during a session in a hyperbaric chamber?

During your hyperbaric oxygen therapy (HBOT) session, you'll relax in a comfortable, pressurized environment designed for a calming experience. Most people find it quiet and soothing, with only minor adjustments, such as a slight ear pressure change—similar to what you feel during takeoff in an airplane.

Are there studies supporting the use of hyperbaric oxygen chambers?

Absolutely! A growing body of scientific studies and research highlights the benefits of hyperbaric oxygen therapy (HBOT) for wellness, recovery, and performance. As interest in HBOT expands, new findings continue to emerge, demonstrating its impact on healing, inflammation reduction, and overall vitality. Check back often—we regularly update this page with the latest research to keep you informed.

Where can I learn more about HBOT studies and purchase a chamber?

Our research page is continuously updated with the latest studies and insights on hyperbaric oxygen therapy (HBOT), reflecting new advancements and the growing interest in its benefits. If you're considering adding a hyperbaric chamber to your wellness routine or office, our team is here to help. We can guide you through the research and assist you in selecting the right chamber for your needs. Contact us today to learn more! 📞 701-987-3044